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Organ cultures

Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL)

Hayley J. Hawkins, Betelehem W. Yacob, Monica E. Brown, Brandon R. Goldstein, John J. Arcaroli, Stacey M. Bagby, Sarah J. Hartman, Morgan Macbeth, Andrew Goodspeed, Thomas Danhorn, Robert W. Lentz, Christopher H. Lieu, Alexis D. Leal, Wells A. Messersmith, Peter J. Dempsey, Todd M. Pitts

published 10 Apr 2024

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Accessible luminal interface of bovine rectal organoids generated from cryopreserved biopsy tissues

Minae Kawasaki, Yoko M. Ambrosini

published 21 Mar 2024

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β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53

Mohamed Bourmoum, Nikolina Radulovich, Amit Sharma, Johnny M. Tkach, Ming-Sound Tsao, Laurence Pelletier

published 07 Feb 2024

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Leader cells mechanically respond to aligned collagen architecture to direct collective migration

Jessanne Y. Lichtenberg, Ella Ramamurthy, Anna D. Young, Trey P. Redman, Corinne E. Leonard, Swadesh K. Das, Paul B. Fisher, Christopher A. Lemmon, Priscilla Y. Hwang

published 02 Jan 2024

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Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells

Chao Li, Zhong Liu, Justin Anderson, Zhongyu Liu, Liping Tang, Yao Li, Ning Peng, Jianguo Chen, Xueming Liu, Lianwu Fu, Tim M. Townes, Steven M. Rowe, David M. Bedwell, Jennifer Guimbellot, Rui Zhao

published 29 Nov 2023

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In depth characterization of midbrain organoids derived from wild type iPSC lines

Ivan Pavlinov, Mitali Tambe, Joshua Abbott, Ha Nam Nguyen, Miao Xu, Manisha Pradhan, Atena Farkhondeh, Wei Zheng

published 20 Oct 2023

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Effects of acute low-moderate dose ionizing radiation to human brain organoids

Foluwasomi A. Oyefeso, Gabriela Goldberg, Nana Yaa P. S. Opoku, Marcelo Vazquez, Antonella Bertucci, Zhong Chen, Charles Wang, Alysson R. Muotri, Michael J. Pecaut

published 31 May 2023

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DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets

Barbara Pucelik, Agata Barzowska, Anna Czarna

published 17 May 2023

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Organoids containing neural-like cells derived from chicken iPSCs respond to poly:IC through the RLR family

Masafumi Katayama, Manabu Onuma, Noriko Kato, Nobuyoshi Nakajima, Tomokazu Fukuda

published 04 May 2023

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Parkin-mediated mitophagy is negatively regulated by FOXO3A, which inhibits Plk3-mediated mitochondrial ROS generation in STZ diabetic stress-treated pancreatic β cells

Ji Yeon Shim, Jin Ook Chung, Dawa Jung, Pil Soo Kang, Seon-Young Park, Ayse Tuba Kendi, Val J. Lowe, SeungBaek Lee

published 03 May 2023

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Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data

Noura Tbeileh, Luika Timmerman, Aras N. Mattis, Kan Toriguchi, Yosuke Kasai, Carlos Corvera, Eric Nakakura, Kenzo Hirose, David B. Donner, Robert S. Warren, Eveliina Karelehto

published 06 Apr 2023

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Identification of cancer-related genes FGFR2 and CEBPB in choledochal cyst via RNA sequencing of patient-derived liver organoids

Yongqin Ye, Vincent Chi Hang Lui, Rosana Ottakandathil Babu, Zhongluan Wu, Weifang Wu, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong, Bin Wang, Paul Kwong Hang Tam

published 30 Mar 2023

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A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology

Xiaoxi Xu, Rajendra Kumari, Jun Zhou, Jing Chen, Binchen Mao, Jingjing Wang, Meiling Zheng, Xiaolong Tu, Xiaoyu An, Xiaobo Chen, Likun Zhang, Xiaoli Tian, Haojie Wang, Xin Dong, Zhengzheng Bao, Sheng Guo, Xuesong Ouyang, Limei Shang, Fei Wang, Xuefei Yan, Rui Zhang, Robert G. J. Vries, Hans Clevers, Qi-Xiang Li

published 05 Jan 2023

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