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Animal models of disease

PERK modulation, with GSK2606414, Sephin1 or salubrinal, failed to produce therapeutic benefits in the SOD1G93A mouse model of ALS

Fernando G. Vieira, Valerie R. Tassinari, Joshua D. Kidd, Andrew Moreno, Kenneth Thompson, Steven Perrin, Alan Gill, Theo Hatzipetros

published 15 Feb 2024

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A murine model to evaluate immunotherapy effectiveness for human Fanconi anemia-mutated acute myeloid leukemia

Tingting Huang, Bernice Leung, Yuyang Huang, Laura Price, Jiang Gui, Bonnie W. Lau

published 30 Jan 2024

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Pathobiology of Candida auris infection analyzed by multiplexed imaging and single cell analysis

Chrystal Chadwick, Magdia De Jesus, Fiona Ginty, Jessica S. Martinez

published 17 Jan 2024

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Two mouse models of Alzheimer’s disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein

Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark Farrow, Andrew J. Nicoll, Dominic Walsh, John Collinge

published 17 Nov 2023

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Signature of cardiac alterations in early and late chronic infections with Trypanosoma cruzi in mice

Bárbara Carolina Arias-Argáez, Victor Manuel Dzul-Huchim, Ana Paulina Haro-Álvarez, Miguel Enrique Rosado-Vallado, Liliana Villanueva-Lizama, Julio Vladimir Cruz-Chan, Eric Dumonteil

published 05 Oct 2023

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ICG-mediated fluorescence-assisted debridement to promote wound healing

Gang Zhu, Benjian Gao, Jun Fan, Jianfei Chen, Song Su, Xiaoli Yang, Bo Li, Cheng Fang

published 21 Sep 2023

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Pneumolysin as a target for new therapies against pneumococcal infections: A systematic review

María Dolores Cima Cabal, Felipe Molina, José Ignacio López-Sánchez, Efrén Pérez-Santín, María del Mar García-Suárez

published 22 Mar 2023

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Immunopathological mechanisms in the early stage of Mycobacterium avium subsp. paratuberculosis infection via different administration routes in a murine model

Jun Ho Lee, Hong-Tae Park, Soojin Shim, Suji Kim, Sang-Ho Woo, Dae-Yong Kim, Han Sang Yoo

published 16 Feb 2023

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A generalized classification and coding system of Human Disease Animal Model Resource data with a case study to show improving database retrieval efficiency

Huiping Li, Wenjuan Zhang

published 09 Feb 2023

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MYB and ELF3 differentially modulate labor-inducing gene expression in myometrial cells

Virlana M. Shchuka, Nawrah Khader, Anna Dorogin, Oksana Shynlova, Jennifer A. Mitchell

published 03 Jan 2023

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β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment

Yu Liu, Qingqing Zhao, Changsong Chen, Chunhu Wu, Yuhai Ma

published 08 Dec 2022

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A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia

Tanila Wood dos Santos, Pedro Almeida Gonçalves, Dunia Rodriguez, José Aires Pereira, Carlos Augusto Real Martinez, Luciana C. C. Leite, Lucio F. C. Ferraz, Thiago Rojas Converso, Michelle Darrieux

published 07 Dec 2022

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Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

Sarah A. Gilmore, Danny Tam, Tara L. Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y. Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M. Brendza, Todd C. Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H. Tay, William E. Delaney IV, Gregory T. Notte, Uli Schmitz, Becket Feierbach

published 07 Dec 2022

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