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Original Article Antiviral Oseltamivir Is not Removed or Degraded in Normal Sewage Water Treatment: Implications for Development of Resistance by Influenza A Virus
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Significant paper Posted by acsinger on 05 Oct 2007 at 08:01 GMT

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    • Currently 4.5/5 Stars.

Fick et al provide experimental evidence of the recalcitrance of oseltamivir carboxylate (active antiviral metabolite of Tamiflu). This work is significant as models for the use of Tamiflu during a pandemic (see: http://www.ehponline.org/docs/2006/9574/abstract.html) predict high concentrations of the drug in riverwater, having assumed no biodegradation in sewage treatment plants. Confirmation of the recalcitrance of Tamiflu further indicates Tamiflu may present serious environmental and human health concerns upon its release.

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