Ratings

This paper is a wonderful example of how valuable and powerful invertebrate model systems are for a wide variety of biological questions ranging from the single molecule all the way up to ecology and evolution.
In our ever warmer world, the evolution of thermotolerance is a key factor in understanding and predicting species distributions. This study uses two different model systems each with its own technical advantages to study the role of the forager gene product (a PKG) in thermotolerance. The role of the for PKG is evolutionarily conserved so the results presented here help understand the general neurobiology and genetics of thermotolerance. The explanatory power and generalizability of the results are typical for this kind of integrative neuroscience.