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Phase I clinical investigation

The impact of the COVID-19 pandemic on scientific research in the life sciences

Massimo Riccaboni, Luca Verginer

A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme—A Preclinical and Phase I Investigation

David Aviezer, Einat Brill-Almon, [ ... ], Eithan Galun

How Frequently Do the Results from Completed US Clinical Trials Enter the Public Domain? - A Statistical Analysis of the ClinicalTrials.gov Database

Hiroki Saito, Christopher J. Gill

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Pirow Bekker, Daniel Dairaghi, [ ... ], Thomas J. Schall

Development of a Simple 12-Item Theory-Based Instrument to Assess the Impact of Continuing Professional Development on Clinical Behavioral Intentions

France Légaré, Francine Borduas, [ ... ], the CPD-KT team

Dose-Finding Based on Bivariate Efficacy-Toxicity Outcome Using Archimedean Copula

Yuxi Tao, Junlin Liu, [ ... ], Fangrong Yan

Efficiency of New Dose Escalation Designs in Dose-Finding Phase I Trials of Molecularly Targeted Agents

Christophe Le Tourneau, Hui K. Gan, Albiruni R. A. Razak, Xavier Paoletti

Neutropenia as an Adverse Event following Vaccination: Results from Randomized Clinical Trials in Healthy Adults and Systematic Review

Vincent Muturi-Kioi, David Lewis, [ ... ], Audino Podda

First Phase 1 Double-Blind, Placebo-Controlled, Randomized Rectal Microbicide Trial Using UC781 Gel with a Novel Index of Ex Vivo Efficacy

Peter A. Anton, Terry Saunders, [ ... ], Ian McGowan

Preclinical Evaluation of the Novel, Orally Bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in Spontaneous Canine Cancer: Results of a Phase I Study

Cheryl A. London, Luis Feo Bernabe, [ ... ], Sharon Shacham

Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis

Beatriz P. Monteiro, Mary P. Klinck, [ ... ], Eric Troncy

The patent buyout price for human papilloma virus (HPV) vaccine and the ratio of R&D costs to the patent value

Mario Songane, Volker Grossmann

Global migration of clinical research during the era of trial registration

Paul K. Drain, Robert A. Parker, Marion Robine, King K. Holmes

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