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Figure 1. Dissection of proteins into dynamical classes.

Hierarchical clustering of proteins, using Ward's method, by their dynamic profiles (upper panel) and the interaction matrix showing the protein-protein interaction patterns between different dynamic profiles (lower panel). In order to make clustering possible, we normalized each row to have a mean of 0 and a variance of 1. For the lower panel, proteins were binned into 114 bins with the exact ordering as in the clustering in the upper panel. Each square in the matrix represents the number of interactions between respective bins.