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Research Article

Neurodegenerative Evidence in Mice Brains with Cecal Ligation and Puncture-Induced Sepsis: Preventive Effect of the Free Radical Scavenger Edaravone

  • Hiroki Yokoo mail,

    hyokoo@med.u-toyama.ac.jp

    Affiliation: Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

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  • Seiichi Chiba,

    Affiliation: Department of Internal Medicine, Faculty of Medicine, Oita University, Yufu, Japan

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  • Kengo Tomita,

    Affiliation: Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

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  • Michinori Takashina,

    Affiliation: Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

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  • Hiroshi Sagara,

    Affiliation: Medical Proteomics Laboratory, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Saburo Yagisita,

    Affiliation: Section of Pathology, Kanagawa Rehabilitation Center, Atsugi, Japan

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  • Yasuo Takano,

    Affiliation: Kanagawa Cancer Research Institute, Yokohama, Japan

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  • Yuichi Hattori

    Affiliation: Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

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  • Published: December 07, 2012
  • DOI: 10.1371/journal.pone.0051539

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