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Open Access
Peer-reviewed
Research Article
BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System
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Niklas Mattsson ,
* E-mail: niklas.mattsson@neuro.gu.se (NM); erik.portelius@neuro.gu.se (EP)
Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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Lawrence Rajendran,
Affiliation Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
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Henrik Zetterberg,
Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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Mikael Gustavsson,
Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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Ulf Andreasson,
Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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Maria Olsson,
Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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Gunnar Brinkmalm,
Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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Johan Lundkvist,
Affiliation Innovative Medicines, Central Nervous System and Pain iMed, Department of Neuroscience, AstraZeneca R&D, Södertälje, Sweden
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Laura H. Jacobson,
Affiliation Neuroscience Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Ludovic Perrot,
Affiliation Neuroscience Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Ulf Neumann,
Affiliation Neuroscience Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Herman Borghys,
Affiliation Neuroscience Therapeutic Area, Janssen Research and Development, Beerse, Belgium
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Marc Mercken,
Affiliation Neuroscience Therapeutic Area, Janssen Research and Development, Beerse, Belgium
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Deborah Dhuyvetter,
Affiliation Neuroscience Therapeutic Area, Janssen Research and Development, Beerse, Belgium
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Fredrik Jeppsson,
Affiliation Innovative Medicines, Central Nervous System and Pain iMed, Department of Neuroscience, AstraZeneca R&D, Södertälje, Sweden
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Kaj Blennow,
Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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Erik Portelius
* E-mail: niklas.mattsson@neuro.gu.se (NM); erik.portelius@neuro.gu.se (EP)
Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System
- Niklas Mattsson,
- Lawrence Rajendran,
- Henrik Zetterberg,
- Mikael Gustavsson,
- Ulf Andreasson,
- Maria Olsson,
- Gunnar Brinkmalm,
- Johan Lundkvist,
- Laura H. Jacobson,
- Ludovic Perrot
- Published: February 6, 2012
- https://doi.org/10.1371/journal.pone.0031084