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Research Article

The Use of Directed Evolution to Create a Stable and Immunogenic Recombinant BCG Expressing a Modified HIV-1 Gag Antigen

  • Rosamund Chapman equal contributor mail,

    equal contributor Contributed equally to this work with: Rosamund Chapman, William R. Bourn

    Ros.Chapman@uct.ac.za

    Affiliation: Division of Virology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    X
  • William R. Bourn equal contributor,

    equal contributor Contributed equally to this work with: Rosamund Chapman, William R. Bourn

    Affiliation: Division of Virology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    Current address: Kapabiosystems, Cape Town, South Africa

    X
  • Enid Shephard,

    Affiliations: Division of Virology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, Medical Research Council, Cape Town, South Africa, Department of Medicine Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    X
  • Helen Stutz,

    Affiliation: Division of Virology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    X
  • Nicola Douglass,

    Affiliation: Division of Virology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    X
  • Thandi Mgwebi,

    Affiliation: Division of Virology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    Current address: Human Capacity Programme, National Research Foundation, Pretoria, South Africa

    X
  • Ann Meyers,

    Affiliation: Department of Molecular and Cell Biology, Faculty Of Science, University of Cape Town, Cape Town, South Africa

    X
  • Nyasha Chin'ombe,

    Affiliation: Division of Virology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    Current address: Department of Medical Microbiology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe

    X
  • Anna-Lise Williamson

    Affiliations: Division of Virology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, National Health Laboratory Services, Cape Town, South Africa

    X
  • Published: July 25, 2014
  • DOI: 10.1371/journal.pone.0103314

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