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Research Article

A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding

  • Hadassah Sade,

    Affiliation: Large Molecule Research, Pharma Research and Early Development (pRED), Roche, Penzberg, Germany

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  • Claudia Baumgartner,

    Affiliation: Large Molecule Research, Pharma Research and Early Development (pRED), Roche, Penzberg, Germany

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  • Adrian Hugenmatter,

    Affiliation: Large Molecule Research, Pharma Research and Early Development (pRED), Roche, Schlieren, Switzerland

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  • Ekkehard Moessner,

    Affiliation: Large Molecule Research, Pharma Research and Early Development (pRED), Roche, Schlieren, Switzerland

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  • Per-Ola Freskgård,

    Affiliation: Neuroscience Discovery and Translation Area, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche, Basel, Switzerland

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  • Jens Niewoehner mail

    jens.niewoehner@roche.com

    Affiliation: Large Molecule Research, Pharma Research and Early Development (pRED), Roche, Penzberg, Germany

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  • Published: April 30, 2014
  • DOI: 10.1371/journal.pone.0096340

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