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Research Article

Admixture Mapping and Subsequent Fine-Mapping Suggests a Biologically Relevant and Novel Association on Chromosome 11 for Type 2 Diabetes in African Americans

  • Janina M. Jeff,

    Affiliation: Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Loren L. Armstrong,

    Affiliation: Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Marylyn D. Ritchie,

    Affiliation: Center for System Genomics, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Joshua C. Denny,

    Affiliations: Department of Medicine, Division of Clinical Pharmacology,Vanderbilt University, Nashville, Tennessee, United States of America, Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Abel N. Kho,

    Affiliation: Division of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Melissa A. Basford,

    Affiliation: Office of Personalized Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Wendy A. Wolf,

    Affiliation: Division of Genetics, Children's Hospital Boston, Boston, Massachusetts, United States of America

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  • Jennifer A. Pacheco,

    Affiliation: Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Rongling Li,

    Affiliation: Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland, United States of America

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  • Rex L. Chisholm,

    Affiliation: Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Dan M. Roden,

    Affiliations: Department of Medicine, Division of Clinical Pharmacology,Vanderbilt University, Nashville, Tennessee, United States of America, Office of Personalized Medicine, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • M. Geoffrey Hayes,

    Affiliations: Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Dana C. Crawford mail

    crawford@chgr.mc.vanderbilt.edu

    Affiliation: Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Published: March 03, 2014
  • DOI: 10.1371/journal.pone.0086931

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