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Research Article

Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice

  • Regan Roat,

    Affiliation: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Vandana Rao,

    Affiliation: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Nicolai M. Doliba,

    Affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Franz M. Matschinsky,

    Affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • John W. Tobias,

    Affiliation: Bioinformatics Group, Penn Molecular Profiling Facility, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Eden Garcia,

    Affiliation: Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

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  • Rexford S. Ahima,

    Affiliation: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Yumi Imai mail

    imaiy@evms.edu

    Affiliations: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

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  • Published: February 05, 2014
  • DOI: 10.1371/journal.pone.0086815

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