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Research Article

Plasma Metabolomics Reveal Alterations of Sphingo- and Glycerophospholipid Levels in Non-Diabetic Carriers of the Transcription Factor 7-Like 2 Polymorphism rs7903146

  • Cornelia Then equal contributor,

    equal contributor Contributed equally to this work with: Cornelia Then, Simone Wahl

    Affiliations: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany, Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany

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  • Simone Wahl equal contributor,

    equal contributor Contributed equally to this work with: Cornelia Then, Simone Wahl

    Affiliation: Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany

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  • Anna Kirchhofer,

    Affiliation: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany

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  • Harald Grallert,

    Affiliations: Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany, Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany

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  • Susanne Krug,

    Affiliations: Else-Kroener-Fresenius-Centre for Nutritional Medicine, ZIEL - Research Centre for Nutrition and Food Sciences, Technical University München, Freising-Weihenstephan, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technical University München and Helmholtz Zentrum München, Munich, Germany

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  • Gabi Kastenmüller,

    Affiliation: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany

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  • Werner Römisch-Margl,

    Affiliation: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany

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  • Melina Claussnitzer,

    Affiliations: Else-Kroener-Fresenius-Centre for Nutritional Medicine, ZIEL - Research Centre for Nutrition and Food Sciences, Technical University München, Freising-Weihenstephan, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technical University München and Helmholtz Zentrum München, Munich, Germany

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  • Thomas Illig,

    Affiliation: Hannover Unified Biobank, Hannover Medical School, Hannover, Germany

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  • Margit Heier,

    Affiliation: Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany

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  • Christa Meisinger,

    Affiliation: Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany

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  • Jerzy Adamski,

    Affiliation: Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany.

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  • Barbara Thorand,

    Affiliations: Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany, German Center for Diabetes Research (DZD), Neuherberg, Germany

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  • Cornelia Huth,

    Affiliations: Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany, German Center for Diabetes Research (DZD), Neuherberg, Germany

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  • Annette Peters,

    Affiliations: Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany

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  • Cornelia Prehn,

    Affiliation: Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany.

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  • Ina Heukamp,

    Affiliation: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany

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  • Helmut Laumen,

    Affiliations: Else-Kroener-Fresenius-Centre for Nutritional Medicine, ZIEL - Research Centre for Nutrition and Food Sciences, Technical University München, Freising-Weihenstephan, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technical University München and Helmholtz Zentrum München, Munich, Germany

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  • Andreas Lechner,

    Affiliations: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany, Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany

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  • Hans Hauner,

    Affiliations: Else-Kroener-Fresenius-Centre for Nutritional Medicine, ZIEL - Research Centre for Nutrition and Food Sciences, Technical University München, Freising-Weihenstephan, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technical University München and Helmholtz Zentrum München, Munich, Germany

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  • Jochen Seissler mail

    jochen.seissler@med.uni-muenchen.de

    Affiliations: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany, Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany

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  • Published: October 24, 2013
  • DOI: 10.1371/journal.pone.0078430

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