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Research Article

High-Throughput Screening (HTS) and Hit Validation to Identify Small Molecule Inhibitors with Activity against NS3/4A proteases from Multiple Hepatitis C Virus Genotypes

  • Hyun Lee,

    Affiliation: Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Tian Zhu,

    Affiliation: Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Kavankumar Patel,

    Affiliation: Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Yan-Yan Zhang,

    Affiliation: Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Lena Truong,

    Affiliation: Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Kirk E. Hevener,

    Affiliation: Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America

    Current address: Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Meridian, Idaho, United States of America

    X
  • Joseph L. Gatuz,

    Affiliation: Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Gitanjali Subramanya,

    Affiliation: Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

    Current address: Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America

    X
  • Hyun-Young Jeong,

    Affiliation: Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Susan L. Uprichard,

    Affiliation: Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

    Current address: Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America

    X
  • Michael E. Johnson mail

    mjohnson@uic.edu

    Affiliation: Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Published: October 09, 2013
  • DOI: 10.1371/journal.pone.0075144

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