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Open Access
Peer-reviewed
Research Article
A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests
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Frederick A. Schroeder,
Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts, United States of America
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Michael C. Lewis,
Affiliation Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Daniel M. Fass,
Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Florence F. Wagner,
Affiliation Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Yan-Ling Zhang,
Affiliation Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Krista M. Hennig,
Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Jennifer Gale,
Affiliation Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Wen-Ning Zhao,
Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Surya Reis,
Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Douglas D. Barker,
Affiliation Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Erin Berry-Scott,
Affiliation Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Sung Won Kim,
Affiliation Medical Department, Brookhaven National Laboratory, Upton, New York, United States of America
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Elizabeth L. Clore,
Affiliation Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Jacob M. Hooker,
Affiliations Department of Radiology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Edward B. Holson,
Affiliation Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Stephen J. Haggarty ,
* E-mail: haggarty@chgr.mgh.harvard.edu (SJH); petryshen@chgr.mgh.harvard.edu (TLP)
Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Tracey L. Petryshen
* E-mail: haggarty@chgr.mgh.harvard.edu (SJH); petryshen@chgr.mgh.harvard.edu (TLP)
Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests
- Frederick A. Schroeder,
- Michael C. Lewis,
- Daniel M. Fass,
- Florence F. Wagner,
- Yan-Ling Zhang,
- Krista M. Hennig,
- Jennifer Gale,
- Wen-Ning Zhao,
- Surya Reis,
- Douglas D. Barker
- Published: August 14, 2013
- https://doi.org/10.1371/journal.pone.0071323