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Open Access
Peer-reviewed
Research Article
Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus
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Daniah Trabzuni ,
Contributed equally to this work with: Daniah Trabzuni, Mina Ryten
Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom, Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Mina Ryten ,
Contributed equally to this work with: Daniah Trabzuni, Mina Ryten
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom
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Warren Emmett,
Affiliation University College London Genetics Institute, University College London, London, United Kingdom
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Adaikalavan Ramasamy,
Affiliation Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, United Kingdom
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Karl J. Lackner,
Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medical Centre Mainz, Mainz, Germany
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Tanja Zeller,
Affiliation University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany
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Robert Walker,
Affiliation MRC Sudden Death Brain Bank Project, University of Edinburgh, Department of Neuropathology, Edinburgh, Scotland, United Kingdom
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Colin Smith,
Affiliation MRC Sudden Death Brain Bank Project, University of Edinburgh, Department of Neuropathology, Edinburgh, Scotland, United Kingdom
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Patrick A. Lewis,
Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom, School of Pharmacy, University of Reading, Whiteknights, Reading, United Kingdom
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Adamantios Mamais,
Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom, Reta Lila Weston Institute of Neurological Studies, London, United Kingdom
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Rohan de Silva,
Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom, Reta Lila Weston Institute of Neurological Studies, London, United Kingdom
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Jana Vandrovcova,
Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom, Reta Lila Weston Institute of Neurological Studies, London, United Kingdom
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International Parkinson Disease Genomics Consortium (IPDGC) ,
¶A full list of IPDGC consortium members is provided in Table S1.
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Dena Hernandez,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Michael A. Nalls,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Manu Sharma,
Affiliation Division of Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
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Sophie Garnier,
Affiliation Pierre and Marie Curie University, Institut National de la Santé et de la Recherche Médicale UMRS 937, Paris, France
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Suzanne Lesage,
Affiliation CRICM, University Pierre et Marie Curie, Institut National de la Santé et de la Recherche Médicale UMRS 975, CNRS UMR 7225, Hospital Pitié-Salpêtrière, Paris, France
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Javier Simon-Sanchez,
Affiliation Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands
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Thomas Gasser,
Affiliation Division of Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
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Peter Heutink,
Affiliation Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands
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Alexis Brice,
Affiliation CRICM, University Pierre et Marie Curie, Institut National de la Santé et de la Recherche Médicale UMRS 975, CNRS UMR 7225, Hospital Pitié-Salpêtrière, Paris, France
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Andrew Singleton,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Huaibin Cai,
Affiliation Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Eric Schadt,
Affiliation Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America
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Nicholas W. Wood,
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom
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Rina Bandopadhyay,
Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom, Reta Lila Weston Institute of Neurological Studies, London, United Kingdom
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Michael E. Weale,
Affiliation Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, United Kingdom
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John Hardy,
Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom, Reta Lila Weston Institute of Neurological Studies, London, United Kingdom
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Vincent Plagnol
* E-mail: v.plagnol@ucl.ac.uk
Affiliation University College London Genetics Institute, University College London, London, United Kingdom
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Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus
- Daniah Trabzuni,
- Mina Ryten,
- Warren Emmett,
- Adaikalavan Ramasamy,
- Karl J. Lackner,
- Tanja Zeller,
- Robert Walker,
- Colin Smith,
- Patrick A. Lewis,
- Adamantios Mamais
- Published: August 13, 2013
- https://doi.org/10.1371/journal.pone.0070724