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Research Article

Nano-Encapsulation of Arsenic Trioxide Enhances Efficacy against Murine Lymphoma Model while Minimizing Its Impact on Ovarian Reserve In Vitro and In Vivo

  • Richard W. Ahn equal contributor,

    equal contributor Contributed equally to this work with: Richard W. Ahn, Susan L. Barrett

    Affiliations: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America

    X
  • Susan L. Barrett equal contributor,

    equal contributor Contributed equally to this work with: Richard W. Ahn, Susan L. Barrett

    Affiliations: Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America, Center for Reproductive Science Reproductive Biology Training Program, Northwestern University, Evanston, Illinois, United States of America

    X
  • Meera R. Raja,

    Affiliation: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America

    X
  • Jennifer K. Jozefik,

    Affiliations: Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America

    X
  • Lidia Spaho,

    Affiliations: Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America

    X
  • Haimei Chen,

    Affiliations: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America

    X
  • Marcel B. Bally,

    Affiliations: Centre for Drug Research and Development, University of British Columbia, Vancouver, British Columbia, Canada, Department of Advanced Therapeutics, BC Cancer Agency, British Columbia, Canada

    X
  • Andrew P. Mazar,

    Affiliations: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America

    X
  • Michael J. Avram,

    Affiliations: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Department of Anesthesiology and Mary Beth Donnelley Clinical Pharmacology Core Facility of the Robert H. Lurie Comprehensive Cancer Center of the Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Jane N. Winter,

    Affiliations: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Department of Medicine, Division of Hematology/Oncology and Lymphoma Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Leo I. Gordon,

    Affiliations: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Department of Medicine, Division of Hematology/Oncology and Lymphoma Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Lonnie D. Shea,

    Affiliations: Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America

    X
  • Thomas V. O’Halloran mail,

    t-ohalloran@northwestern.edu (TVO); tkw@northwestern.edu (TKW)

    Affiliations: Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America

    X
  • Teresa K. Woodruff mail

    t-ohalloran@northwestern.edu (TVO); tkw@northwestern.edu (TKW)

    Affiliations: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America, Member of the Oncofertility Consortium, Northwestern University, Chicago, Illinois, United States of America, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, United States of America

    X
  • Published: March 20, 2013
  • DOI: 10.1371/journal.pone.0058491

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