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Research Article

Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner

  • Julian I. Borissoff mail,

    j.ilcheff@maastrichtuniversity.nl

    Affiliations: Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jeroen J. T. Otten,

    Affiliation: Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

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  • Sylvia Heeneman,

    Affiliation: Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

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  • Peter Leenders,

    Affiliation: Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

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  • René van Oerle,

    Affiliation: Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

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  • Oliver Soehnlein,

    Affiliation: Institute for Cardiovascular Molecular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany

    Current address: Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University (LMU), Munich, Germany

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  • Sarah T. B. G. Loubele,

    Affiliation: Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

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  • Karly Hamulyák,

    Affiliation: Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

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  • Tilman M. Hackeng,

    Affiliation: Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

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  • Mat J. A. P. Daemen,

    Affiliation: Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

    Current address: Department of Pathology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands

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  • Jay L. Degen,

    Affiliation: Developmental Biology, Children’s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Hartmut Weiler,

    Affiliation: Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, United States of America

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  • Charles T. Esmon,

    Affiliation: Oklahoma Medical Research Foundation and Howard Hughes Medical Institute, Oklahoma City, Oklahoma, United States of America

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  • Joanne van Ryn,

    Affiliation: Department of CardioMetabolic Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

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  • Erik A. L. Biessen,

    Affiliation: Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

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  • Henri M. H. Spronk,

    Affiliation: Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

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  • Hugo ten Cate

    Affiliation: Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

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  • Published: February 07, 2013
  • DOI: 10.1371/journal.pone.0055784

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