Advertisement
Research Article

Combination of a Proteomics Approach and Reengineering of Meso Scale Network Models for Prediction of Mode-of-Action for Tyrosine Kinase Inhibitors

  • Stefan Balabanov,

    Affiliations: Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany, Division of Hematology, University Hospital Zürich, Zürich, Switzerland

    X
  • Thomas Wilhelm,

    Affiliations: Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany, Department of Biochemistry, University Hospital Aachen (UKA) of the Rheinisch.-Westfälische Technische Hochschule Aachen, Aachen, Germany

    X
  • Simone Venz,

    Affiliations: Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Greifswald, Germany, Interfacultary Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

    X
  • Gunhild Keller,

    Affiliation: Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

    X
  • Christian Scharf,

    Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Greifswald, Greifswald, Germany

    X
  • Heike Pospisil,

    Affiliation: Bioinformatics, University of Applied Sciences Wildau, Wildau, Germany

    X
  • Melanie Braig,

    Affiliation: Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

    X
  • Christine Barett,

    Affiliation: Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

    X
  • Carsten Bokemeyer,

    Affiliation: Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

    X
  • Reinhard Walther,

    Affiliation: Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Greifswald, Germany

    X
  • Tim H. Brümmendorf equal contributor,

    equal contributor Contributed equally to this work with: Tim H. Brümmendorf, Andreas Schuppert

    Affiliations: Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany, Medizinische Klinik IV - Hämatologie und Onkologie, Universitätsklinikum Aachen (UKA) of the Rheinisch.-Westfälische Technische Hochschule Aachen, Aachen, Germany

    X
  • Andreas Schuppert equal contributor mail

    equal contributor Contributed equally to this work with: Tim H. Brümmendorf, Andreas Schuppert

    schuppert@aices.rwth-aachen.de

    Affiliation: Aachen Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen University, Aachen, Germany

    X
  • Published: January 09, 2013
  • DOI: 10.1371/journal.pone.0053668

Media Coverage of this Article

Found additional news media or blog coverage for the article? Please let us know.