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Research Article

[18F]FLT and [18F]FDG PET for Non-invasive Treatment Monitoring of the Nicotinamide Phosphoribosyltransferase Inhibitor APO866 in Human Xenografts

  • Mette Munk Jensen mail,

    mettemj@sund.ku.dk

    Affiliations: Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Kamille Dumong Erichsen,

    Affiliation: TopoTarget A/S, Symbion Science Park, Copenhagen, Denmark

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  • Camilla Bardram Johnbeck,

    Affiliations: Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Fredrik Björkling,

    Affiliation: TopoTarget A/S, Symbion Science Park, Copenhagen, Denmark

    Current address: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Jacob Madsen,

    Affiliation: Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Michael Bzorek,

    Affiliation: Department of Pathology, Næstved Hospital, Næstved, Denmark

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  • Peter Buhl Jensen,

    Affiliation: TopoTarget A/S, Symbion Science Park, Copenhagen, Denmark

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  • Liselotte Højgaard,

    Affiliations: Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Maxwell Sehested,

    Affiliation: TopoTarget A/S, Symbion Science Park, Copenhagen, Denmark

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  • Andreas Kjær

    Affiliations: Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Published: January 04, 2013
  • DOI: 10.1371/journal.pone.0053410

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