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Research Article

Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Disease

  • Jonathan D. Cherry,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Bin Liu,

    Affiliation: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jeffrey L. Frost,

    Affiliation: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Cynthia A. Lemere,

    Affiliation: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jacqueline P. Williams,

    Affiliation: Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • John A. Olschowka,

    Affiliation: Department of Neurobiology & Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • M. Kerry O’Banion mail

    Kerry_Obanion@urmc.rochester.edu

    Affiliation: Department of Neurobiology & Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Published: December 31, 2012
  • DOI: 10.1371/journal.pone.0053275

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