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Research Article

Somatic Mutations of PIK3R1 Promote Gliomagenesis

  • Steven N. Quayle,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Jennifer Y. Lee,

    Affiliations: Division of Signal Transduction, Cancer Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Lydia W T. Cheung,

    Affiliation: Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Li Ding,

    Affiliations: The Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Ruprecht Wiedemeyer,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Robert W. Dewan,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Emmet Huang-Hobbs,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Li Zhuang,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Richard K. Wilson,

    Affiliations: The Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America

    X
  • Keith L. Ligon,

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Gordon B. Mills,

    Affiliation: Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Lewis C. Cantley,

    Affiliations: Division of Signal Transduction, Cancer Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lynda Chin mail

    lchin@mdanderson.org

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    Current address: Department of Genomic Medicine and Institute for Applied Cancer Science, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0049466

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