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Research Article

Novel Agents Targeting the IGF-1R/PI3K Pathway Impair Cell Proliferation and Survival in Subsets of Medulloblastoma and Neuroblastoma

  • Anna Wojtalla,

    Affiliation: Division of Pediatric Hematology/Oncology, Department of Clinical Research, University of Bern, Bern, Switzerland

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  • Fabiana Salm,

    Affiliation: Division of Pediatric Hematology/Oncology, Department of Clinical Research, University of Bern, Bern, Switzerland

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  • Ditte G. Christiansen,

    Affiliation: Division of Pediatric Hematology/Oncology, Department of Clinical Research, University of Bern, Bern, Switzerland

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  • Tiziana Cremona,

    Affiliation: Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland

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  • Paulina Cwiek,

    Affiliation: Division of Pediatric Hematology/Oncology, Department of Clinical Research, University of Bern, Bern, Switzerland

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  • Tarek Shalaby,

    Affiliation: Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland

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  • Nicole Gross,

    Affiliation: Department of Pediatrics, Pediatric Oncology Research, University Hospital CHUV, Lausanne, Switzerland

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  • Michael A. Grotzer,

    Affiliation: Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland

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  • Alexandre Arcaro mail

    alexandre.arcaro@dkf.unibe.ch

    Affiliation: Division of Pediatric Hematology/Oncology, Department of Clinical Research, University of Bern, Bern, Switzerland

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0047109

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