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Research Article

Thr 163 Phosphorylation Causes Mcl-1 Stabilization when Degradation Is Independent of the Adjacent GSK3-Targeted Phosphodegron, Promoting Drug Resistance in Cancer

  • Shanna K. Nifoussi equal contributor,

    equal contributor Contributed equally to this work with: Shanna K. Nifoussi, Julie A. Vrana

    Affiliations: Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States of America

    X
  • Julie A. Vrana equal contributor,

    equal contributor Contributed equally to this work with: Shanna K. Nifoussi, Julie A. Vrana

    Current address: Immunostains Laboratory, Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Aaron M. Domina,
  • Alfredo De Biasio,
  • Jingang Gui,
  • Mark A. Gregory,
  • Stephen R. Hann,

    Affiliation: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Ruth W. Craig mail

    Ruth.W.Craig@Dartmouth.edu

    Affiliations: Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States of America

    X
  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0047060

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