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Research Article

CD154 and IL-2 Signaling of CD4+ T Cells Play a Critical Role in Multiple Phases of CD8+ CTL Responses Following Adenovirus Vaccination

  • Channakeshava Sokke Umeshappa,

    Affiliations: Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, Departments of Oncology and Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Current address: Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

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  • Roopa Hebbandi Nanjundappa,

    Affiliation: Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Current address: Department of Microbiology, Immunology & Infectious Diseases, Health Research Innovation Centre, University of Calgary, Calgary, Alberta, Canada

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  • Yufeng Xie,

    Affiliation: Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

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  • Andrew Freywald,

    Affiliation: Departments of Oncology and Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

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  • Yulin Deng,

    Affiliation: Beijing Institute of Technology, Beijing, China

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  • Hong Ma,

    Affiliation: Beijing Institute of Technology, Beijing, China

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  • Jim Xiang mail

    jim.xiang@saskcancer.ca

    Affiliations: Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, Departments of Oncology and Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, Beijing Institute of Technology, Beijing, China

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0047004

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