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Research Article

EGFR Inhibition Abrogates Leiomyosarcoma Cell Chemoresistance through Inactivation of Survival Pathways and Impairment of CSC Potential

  • Giovanni Sette,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Valentina Salvati,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Lorenzo Memeo,

    Affiliation: Mediterranean Institute of Oncology, Catania, Italy

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  • Katia Fecchi,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Cristina Colarossi,

    Affiliation: Mediterranean Institute of Oncology, Catania, Italy

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  • Paola Di Matteo,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Michele Signore,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Mauro Biffoni,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Vito D’Andrea,

    Affiliation: Department of Surgical Sciences, La Sapienza University of Rome, Italy

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  • Enrico De Antoni,

    Affiliation: Department of Surgical Sciences, La Sapienza University of Rome, Italy

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  • Vincenzo Canzonieri,

    Affiliation: Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy

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  • Ruggero De Maria,

    Affiliation: Regina Elena National Cancer Institute, Rome, Italy

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  • Adriana Eramo mail

    adriana.eramo@iss.it

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046891

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