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Research Article

Bioengineered Nisin A Derivatives with Enhanced Activity against Both Gram Positive and Gram Negative Pathogens

  • Des Field,

    Affiliation: Department of Microbiology, University College Cork, Cork, Ireland

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  • Maire Begley,

    Affiliation: Department of Microbiology, University College Cork, Cork, Ireland

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  • Paula M. O’Connor,

    Affiliation: Teagasc, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland

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  • Karen M. Daly,

    Affiliation: Department of Microbiology, University College Cork, Cork, Ireland

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  • Floor Hugenholtz,

    Affiliation: Department of Microbiology, University College Cork, Cork, Ireland

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  • Paul D. Cotter mail,

    paul.cotter@teagasc.ie (PDC); c.hill@ucc.ie (CH)

    Affiliations: Teagasc, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • Colin Hill mail,

    paul.cotter@teagasc.ie (PDC); c.hill@ucc.ie (CH)

    Affiliations: Department of Microbiology, University College Cork, Cork, Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • R. Paul Ross

    Affiliations: Teagasc, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046884

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