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Research Article

Matrine Induces Apoptosis in Human Acute Myeloid Leukemia Cells via the Mitochondrial Pathway and Akt Inactivation

  • Shenghui Zhang,

    Affiliations: Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China, Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China

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  • Yan Zhang,

    Affiliation: Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China

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  • Yan Zhuang,

    Affiliation: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China

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  • Jiajie Wang,

    Affiliation: Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China

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  • Jianqin Ye,

    Affiliation: Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China

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  • Si Zhang,

    Affiliation: Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China

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  • Jianbo Wu,

    Affiliation: Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China

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  • Kang Yu,

    Affiliation: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China

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  • Yixiang Han mail

    yxhan2001@163.com

    Affiliation: Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046853

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