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Research Article

Neurovirulence of H5N1 Infection in Ferrets Is Mediated by Multifocal Replication in Distinct Permissive Neuronal Cell Regions

  • Jennifer R. Plourde,

    Affiliations: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • John A. Pyles,

    Affiliation: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America

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  • R. Colby Layton,

    Affiliation: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America

    Current address: Virology and Infectious Disease Animal Models, MRIGlobal, Kansas City, Missouri, United States of America

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  • Sarah E. Vaughan,

    Affiliations: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Jennifer L. Tipper,

    Affiliation: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America

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  • Kevin S. Harrod mail

    kharrod@lrri.org

    Affiliations: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046605

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