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Research Article

Human Surfactant Protein A2 Gene Mutations Impair Dimmer/Trimer Assembly Leading to Deficiency in Protein Sialylation and Secretion

  • Yi Song equal contributor,

    equal contributor Contributed equally to this work with: Yi Song, Guodong Fang

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Guodong Fang equal contributor,

    equal contributor Contributed equally to this work with: Yi Song, Guodong Fang

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Haitao Shen,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Hui Li,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Wenbing Yang,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Bing Pan,

    Affiliation: The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing, People’s Republic of China

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  • Guowei Huang,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Guangyu Lin,

    Affiliations: Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China, Translational Medicine Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Lian Ma,

    Affiliations: Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China, Translational Medicine Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Belinda Willard,

    Affiliation: Proteomics Laboratory, Cleveland Clinic, Cleveland, Ohio, United States of America

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  • Jiang Gu,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Lemin Zheng mail,

    yywangut@gmail.com (YW); zhengl@bjmu.edu.cn (LZ)

    Affiliation: The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing, People’s Republic of China

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  • Yongyu Wang mail

    yywangut@gmail.com (YW); zhengl@bjmu.edu.cn (LZ)

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046559

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