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Research Article

Humanized Mouse Model of Skin Inflammation Is Characterized by Disturbed Keratinocyte Differentiation and Influx of IL-17A Producing T Cells

  • Vivian L. de Oliveira,

    Affiliation: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Romy R. M. C. Keijsers,

    Affiliations: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Peter C. M. van de Kerkhof,

    Affiliation: Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Marieke M. B. Seyger,

    Affiliation: Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Esther Fasse,

    Affiliation: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Lars Svensson,

    Affiliation: Department of Disease Pharmacology, LEO Pharma, Ballerup, Denmark

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  • Markus Latta,

    Affiliation: Department of Disease Pharmacology, LEO Pharma, Ballerup, Denmark

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  • Hanne Norsgaard,

    Affiliation: Department of Molecular Biomedicine, LEO Pharma, Ballerup, Denmark

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  • Tord Labuda,

    Affiliation: Department of Molecular Biomedicine, LEO Pharma, Ballerup, Denmark

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  • Pieter Hupkens,

    Affiliation: Department of Plastic Surgery Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Piet E. J. van Erp,

    Affiliation: Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Irma Joosten,

    Affiliation: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Hans J. P. M. Koenen mail

    h.koenen@labgk.umcn.nl

    Affiliation: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Published: October 19, 2012
  • DOI: 10.1371/journal.pone.0045509

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