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Research Article

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

  • Adaikalavan Ramasamy equal contributor,

    equal contributor Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

    Affiliations: Respiratory Epidemiology and Public Health, Imperial College London, London, United Kingdom, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Department of Medical and Molecular Genetics, King’s College London, London, United Kingdom

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  • Mikko Kuokkanen equal contributor,

    equal contributor Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

    X
  • Sailaja Vedantam equal contributor,

    equal contributor Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

    Affiliations: Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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  • Zofia K. Gajdos equal contributor,

    equal contributor Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

    Affiliations: Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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  • Alexessander Couto Alves,

    Affiliation: Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

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  • Helen N. Lyon,

    Affiliations: Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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  • Manuel A. R. Ferreira,

    Affiliation: The Queensland Institute of Medical Research, Brisbane, Australia

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  • David P. Strachan,

    Affiliation: Division of Community Health Sciences, St George’s, University of London, London, United Kingdom

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  • Jing Hua Zhao,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom

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  • Michael J. Abramson,

    Affiliation: Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia,

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  • Matthew A. Brown,

    Affiliation: University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia

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  • Lachlan Coin,

    Affiliation: Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

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  • Shyamali C. Dharmage,

    Affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia

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  • David L. Duffy,

    Affiliation: The Queensland Institute of Medical Research, Brisbane, Australia

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  • Tari Haahtela,

    Affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland

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  • Andrew C. Heath,

    Affiliation: Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Christer Janson,

    Affiliation: Department of Medical Sciences: Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden

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  • Mika Kähönen,

    Affiliation: Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

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  • Kay-Tee Khaw,

    Affiliation: Clinical Gerontology Unit, Addenbrooke’s Hospital, Cambridge, United Kingdom

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  • Jaana Laitinen,

    Affiliation: Finnish Institute of Occupational Health, Oulu, Finland

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  • Peter Le Souef,

    Affiliation: School of Paediatrics and Child Health, Princess Margaret Hospital for Children, Perth, Australia

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  • Terho Lehtimäki,

    Affiliation: Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Australian Asthma Genetics Consortium collaborators,

    Collaborators of the Asthma Genetics Consortium are listed in Supplementary Methods S1.

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  • Pamela A. F. Madden,

    Affiliation: Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Guy B. Marks,

    Affiliation: Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia

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  • Nicholas G. Martin,

    Affiliation: The Queensland Institute of Medical Research, Brisbane, Australia

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  • Melanie C. Matheson,

    Affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia

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  • Cameron D. Palmer,

    Affiliations: Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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  • Aarno Palotie,

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland, Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

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  • Anneli Pouta,

    Affiliations: Department of Children, Young People and Families, National Institute for Health and Welfare, Helsinki, Finland, Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland

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  • Colin F. Robertson,

    Affiliation: Respiratory Medicine, Murdoch Children’s Research Institute, Melbourne, Australia

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  • Jorma Viikari,

    Affiliation: Department of Medicine, University of Turku, Turku, Finland

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  • Elisabeth Widen,

    Affiliation: Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

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  • Matthias Wjst,

    Affiliation: Helmholtz Zentrum Munchen German Research Center for Environmental Health, Munich-Neuherberg, Germany

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  • Deborah L. Jarvis,

    Affiliations: Respiratory Epidemiology and Public Health, Imperial College London, London, United Kingdom, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, United Kingdom

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  • Grant W. Montgomery,

    Affiliation: The Queensland Institute of Medical Research, Brisbane, Australia

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  • Philip J. Thompson,

    Affiliation: Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Australia

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  • Nick Wareham,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom

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  • Johan Eriksson,

    Affiliations: National Institute for Health and Welfare, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Folkhälsan Research Center, Helsinki, Finland

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  • Pekka Jousilahti,

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Tarja Laitinen,

    Affiliations: Department of Pulmonary Diseases and Clinical Allergology, Turku University Hospital, Turku, Finland, University of Turku, Turku, Finland

    X
  • Juha Pekkanen,

    Affiliations: Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

    X
  • Olli T. Raitakari,

    Affiliations: Research Centre of Applied and Preventive Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology, Turku University Hospital, Turku, Finland

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  • George T. O'Connor,

    Affiliations: Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, The National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America

    X
  • Veikko Salomaa equal contributor mail,

    equal contributor Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

    joelh@broadinstitute.org (JNH); m.jarvelin@imperial.ac.uk (M-RJ); veikko.salomaa@thl.fi (VS)

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

    X
  • Marjo-Riitta Jarvelin equal contributor mail,

    equal contributor Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

    joelh@broadinstitute.org (JNH); m.jarvelin@imperial.ac.uk (M-RJ); veikko.salomaa@thl.fi (VS)

    Affiliations: Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, United Kingdom, National Institute for Health and Welfare, Helsinki, Finland, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland

    X
  • Joel N. Hirschhorn equal contributor mail

    equal contributor Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

    joelh@broadinstitute.org (JNH); m.jarvelin@imperial.ac.uk (M-RJ); veikko.salomaa@thl.fi (VS)

    Affiliations: Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: September 28, 2012
  • DOI: 10.1371/journal.pone.0044008

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Linked Articles

Correction: Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Alexessander Couto Alves, Helen N. Lyon, Manuel A. R. Ferreira, David P. Strachan, Jing Hua Zhao, Michael J. Abramson, Matthew A. Brown, ...
Correction | published 4 Mar 2013 | PLOS ONE
doi:10.1371/annotation/9630862b-4676-4b82-9869-8d8fbb2a2e65