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Research Article

Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases

  • Gustavo Arruda Bezerra equal contributor,

    equal contributor Contributed equally to this work with: Gustavo Arruda Bezerra, Elena Dobrovetsky

    Affiliation: Institute of Molecular Biosciences, University of Graz, Graz, Austria

    X
  • Elena Dobrovetsky equal contributor,

    equal contributor Contributed equally to this work with: Gustavo Arruda Bezerra, Elena Dobrovetsky

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

    X
  • Aiping Dong,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

    X
  • Almagul Seitova,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

    X
  • Lissete Crombett,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

    X
  • Lisa M. Shewchuk,

    Affiliation: GlaxoSmithKline, Computational and Structural Chemistry, North Carolina, United States of America

    X
  • Annie M. Hassell,

    Affiliation: GlaxoSmithKline, Computational and Structural Chemistry, North Carolina, United States of America

    X
  • Sharon M. Sweitzer,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

    X
  • Thomas D. Sweitzer,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

    X
  • Patrick J. McDevitt,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

    X
  • Kyung O. Johanson,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

    X
  • Karen M. Kennedy-Wilson,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

    X
  • Doug Cossar,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

    X
  • Alexey Bochkarev,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

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  • Karl Gruber mail,

    karl.gruber@uni-graz.at (KG); sirano.dhepaganon@utoronto.ca (SD-P)

    Affiliation: Institute of Molecular Biosciences, University of Graz, Graz, Austria

    X
  • Sirano Dhe-Paganon mail

    karl.gruber@uni-graz.at (KG); sirano.dhepaganon@utoronto.ca (SD-P)

    Affiliations: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

    X
  • Published: August 29, 2012
  • DOI: 10.1371/journal.pone.0043019

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