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Open Access
Peer-reviewed
Research Article
A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo
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Aaron Petty ,
Contributed equally to this work with: Aaron Petty, Eugene Myshkin, Haina Qin
Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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Eugene Myshkin ,
Contributed equally to this work with: Aaron Petty, Eugene Myshkin, Haina Qin
Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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Haina Qin ,
Contributed equally to this work with: Aaron Petty, Eugene Myshkin, Haina Qin
Affiliation Departments of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore
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Hong Guo,
Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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Hui Miao,
Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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Gregory P. Tochtrop,
Affiliations Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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Jer-Tsong Hsieh,
Affiliation Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
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Phillip Page,
Affiliation Reichert, Inc., Depew, New York, United States of America
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Lili Liu,
Affiliation Department of Medicine, Division of Hematology and Oncology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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Daniel J. Lindner,
Affiliation Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America
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Chayan Acharya,
Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
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Alexander D. MacKerell Jr,
Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
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Eckhard Ficker,
Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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Jianxing Song ,
* E-mail: bchsj@nus.edu.sg (JS); bxw14@case.edu (BW)
Affiliations Departments of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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Bingcheng Wang
* E-mail: bchsj@nus.edu.sg (JS); bxw14@case.edu (BW)
Affiliations Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo
- Aaron Petty,
- Eugene Myshkin,
- Haina Qin,
- Hong Guo,
- Hui Miao,
- Gregory P. Tochtrop,
- Jer-Tsong Hsieh,
- Phillip Page,
- Lili Liu,
- Daniel J. Lindner
- Published: August 15, 2012
- https://doi.org/10.1371/journal.pone.0042120