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Research Article

Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms

  • Stéphanie Lucas,

    Affiliation: Laboratory of Neuroimmunoendocrinology, Institut Fédératif de Recherche (IFR) 142, Univ Lille Nord de France, Institut Pasteur, Lille, France

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  • Solenne Taront,

    Affiliation: Laboratory of Genomics and Metabolic Diseases, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Univ Lille Nord de France, Institut Pasteur, Lille, France

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  • Christophe Magnan,

    Affiliation: Laboratory of Physiopathology of Nutrition, CNRS UMR 7059, Paris 7 Univ, Paris, France

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  • Laurence Fauconnier,

    Affiliation: Laboratory of Cellular Immunopathology of Infectious Diseases, CNRS UMR 8527, Institut de Biologie/Institut Pasteur, Lille, France

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  • Myriam Delacre,

    Affiliation: Laboratory of Neuroimmunoendocrinology, Institut Fédératif de Recherche (IFR) 142, Univ Lille Nord de France, Institut Pasteur, Lille, France

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  • Laurence Macia,

    Affiliation: Laboratory of Neuroimmunoendocrinology, Institut Fédératif de Recherche (IFR) 142, Univ Lille Nord de France, Institut Pasteur, Lille, France

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  • Anne Delanoye,

    Affiliation: Laboratory of Neuroimmunoendocrinology, Institut Fédératif de Recherche (IFR) 142, Univ Lille Nord de France, Institut Pasteur, Lille, France

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  • Claudie Verwaerde,

    Affiliation: Laboratory of Neuroimmunoendocrinology, Institut Fédératif de Recherche (IFR) 142, Univ Lille Nord de France, Institut Pasteur, Lille, France

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  • Corentin Spriet,

    Affiliation: Interdisciplinary Research Institute, CNRS Unité de Service et de Recherche (USR) 3078, Univ Lille Nord de France, Villeneuve d’Ascq, France

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  • Pasquine Saule,

    Affiliation: Laboratory of Cellular Immunopathology of Infectious Diseases, CNRS UMR 8527, Institut de Biologie/Institut Pasteur, Lille, France

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  • Gautier Goormachtigh,

    Affiliation: Laboratory of Cellular Immunopathology of Infectious Diseases, CNRS UMR 8527, Institut de Biologie/Institut Pasteur, Lille, France

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  • Laurent Héliot,

    Affiliation: Interdisciplinary Research Institute, CNRS Unité de Service et de Recherche (USR) 3078, Univ Lille Nord de France, Villeneuve d’Ascq, France

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  • Alain Ktorza,

    Affiliation: Laboratory of Physiopathology of Nutrition, CNRS UMR 7059, Paris 7 Univ, Paris, France

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  • Jamileh Movassat,

    Affiliation: Laboratory of Biology and Pathology of the Endocrine Pancreas, CNRS Equipe d’Accueil Conventionnée (EAC) 4413, Paris 7 Univ, Paris, France

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  • Renata Polakowska,

    Affiliation: Inserm U837 and Jean-Pierre Aubert Research Center, Centre Hospitalier Universitaire (CHU), Univ Lille Nord de France, Lille, France

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  • Claude Auriault,

    Affiliation: Laboratory of Cellular Immunopathology of Infectious Diseases, CNRS UMR 8527, Institut de Biologie/Institut Pasteur, Lille, France

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  • Odile Poulain-Godefroy,

    Affiliation: Laboratory of Genomics and Metabolic Diseases, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Univ Lille Nord de France, Institut Pasteur, Lille, France

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  • James Di Santo,

    Affiliations: Innate Immunity Unit, Institut Pasteur, Paris, France, Inserm U668, Paris, France

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  • Philippe Froguel,

    Affiliation: Laboratory of Genomics and Metabolic Diseases, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Univ Lille Nord de France, Institut Pasteur, Lille, France

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  • Isabelle Wolowczuk mail

    Isabelle.Wolowczuk@good.ibl.fr

    Affiliation: Laboratory of Genomics and Metabolic Diseases, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Univ Lille Nord de France, Institut Pasteur, Lille, France

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  • Published: June 29, 2012
  • DOI: 10.1371/journal.pone.0040351

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