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Research Article

Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells

  • Yu-Jen Chen,

    Affiliations: Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan, Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan

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  • Cheng-Deng Kuo,

    Affiliation: Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan

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  • Szu-Han Chen,

    Affiliation: Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan

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  • Wei-Jen Chen,

    Affiliation: Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan

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  • Wen-Chien Huang,

    Affiliation: Division of Thoracic Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan

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  • K. S. Clifford Chao,

    Affiliation: Department of Radiation Oncology, Columbia University, New York, New York, United States of America

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  • Hui-Fen Liao mail

    liaohf@seed.net.tw

    Affiliations: Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan

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  • Published: May 15, 2012
  • DOI: 10.1371/journal.pone.0037006

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