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Research Article

PGC-1α Induces Mitochondrial and Myokine Transcriptional Programs and Lipid Droplet and Glycogen Accumulation in Cultured Human Skeletal Muscle Cells

  • Emma Mormeneo mail,

    emormeneo@ub.edu

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Bioquímica i Biologia Molecular, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

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  • Cecilia Jimenez-Mallebrera,

    Affiliation: Unitat de Patologia Neuromuscular, Servei de Neurologia, Hospital Sant Joan de Déu, Barcelona, Spain

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  • Xavier Palomer,

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Farmacologia i Química Terapèutica, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

    X
  • Valeria De Nigris,

    Affiliation: Diabetes and Obesity Laboratory, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona; Spain

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  • Manuel Vázquez-Carrera,

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Farmacologia i Química Terapèutica, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

    X
  • Anna Orozco,

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Bioquímica i Biologia Molecular, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

    X
  • Andrés Nascimento,

    Affiliation: Unitat de Patologia Neuromuscular, Servei de Neurologia, Hospital Sant Joan de Déu, Barcelona, Spain

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  • Jaume Colomer,

    Affiliation: Unitat de Patologia Neuromuscular, Servei de Neurologia, Hospital Sant Joan de Déu, Barcelona, Spain

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  • Carles Lerín,

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Diabetes and Obesity Laboratory, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona; Spain

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  • Anna M. Gómez-Foix

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Bioquímica i Biologia Molecular, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

    X
  • Published: January 17, 2012
  • DOI: 10.1371/journal.pone.0029985

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