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Research Article

A Single Base-Pair Change in 2009 H1N1 Hemagglutinin Increases Human Receptor Affinity and Leads to Efficient Airborne Viral Transmission in Ferrets

  • Akila Jayaraman,

    Affiliation: Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

    X
  • Claudia Pappas,

    Affiliation: Influenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America

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  • Rahul Raman,

    Affiliation: Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

    X
  • Jessica A. Belser,

    Affiliation: Influenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America

    X
  • Karthik Viswanathan,

    Affiliation: Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

    X
  • Zachary Shriver,

    Affiliation: Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

    X
  • Terrence M. Tumpey,

    Affiliation: Influenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America

    X
  • Ram Sasisekharan mail

    rams@mit.edu

    Affiliation: Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

    X
  • Published: March 02, 2011
  • DOI: 10.1371/journal.pone.0017616

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