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Research Article

Chronic CSE Treatment Induces the Growth of Normal Oral Keratinocytes via PDK2 Upregulation, Increased Glycolysis and HIF1α Stabilization

  • Wenyue Sun,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Steven S. Chang,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Yumei Fu,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Yan Liu,

    Affiliation: Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Joseph A. Califano mail

    jcalifa@jhmi.edu

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland, United States of America

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  • Published: January 19, 2011
  • DOI: 10.1371/journal.pone.0016207

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