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Open Access
Peer-reviewed
Research Article
The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine
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Hayley C. Whitaker ,
* E-mail: Hayley.Whitaker@cancer.org.uk
Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom
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Zsofia Kote-Jarai ,
Contributed equally to this work with: Zsofia Kote-Jarai, Helen Ross-Adams
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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Helen Ross-Adams ,
Contributed equally to this work with: Zsofia Kote-Jarai, Helen Ross-Adams
Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom
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Anne Y. Warren,
Affiliation Department of Pathology, Addenbrookes Hospital, Cambridge, United Kingdom
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Johanna Burge,
Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom
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Anne George,
Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom
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Elizabeth Bancroft,
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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Sameer Jhavar,
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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Daniel Leongamornlert,
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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Malgorzata Tymrakiewicz,
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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Edward Saunders,
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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Elizabeth Page,
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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Anita Mitra,
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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Gillian Mitchell,
Affiliation Peter Maccallum Cancer Centre, Victoria, Australia
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Geoffrey J. Lindeman,
Affiliation The Royal Melbourne Hospital and The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
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D. Gareth Evans,
Affiliation Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
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Ignacio Blanco,
Affiliation Catalonian Institute of Oncology, L'Hospitalet, Barcelona, Spain
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Catherine Mercer,
Affiliation Wessex Clinical Genetics Service, The Princess Anne Hospital, Southampton, United Kingdom
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Wendy S. Rubinstein,
Affiliation NorthShore University Health System, Evanston, Illinois, United States of America
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Virginia Clowes,
Affiliation Department of Clinical Genetics, Addenbrookes Hospital, Cambridge, United Kingdom
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Fiona Douglas,
Affiliation Institute of Human Genetics, Newcastle-Upon-Tyne, United Kingdom
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Shirley Hodgson,
Affiliation St George's, University of London, London, United Kingdom
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Lisa Walker,
Affiliation Oxford Regional Genetics Centre, Churchill Hospital, Oxford, United Kingdom
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Alan Donaldson,
Affiliation St Michael's Hospital, Bristol, United Kingdom
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Louise Izatt,
Affiliation Guy's Hospital, London, United Kingdom
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Huw Dorkins,
Affiliation Kennedy Galton Centre, Northwick Park Hospital, Harrow, Middlesex, United Kingdom
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Alison Male,
Affiliation Institute of Child Health, London, United Kingdom
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Kathy Tucker,
Affiliation Prince of Wales Hospital, Sydney, New South Wales, Australia
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Alan Stapleton,
Affiliation Repatriation General Hospital, Adelaide, Australia
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Jimmy Lam,
Affiliation Repatriation General Hospital, Adelaide, Australia
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Judy Kirk,
Affiliation Familial Cancer Service, Westmead Hospital, Westmead, New South Wales, Australia
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Hans Lilja,
Affiliation Departments of Clinical Laboratories, Surgery, Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Douglas Easton,
Affiliation Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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The IMPACT Study Steering Committee ,
¶List of The IMPACT Study Steering Committee available on request.
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The IMPACT Study Collaborators ,
¶List of The IMPACT Study Collaborators available on request.
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UK GPCS Collaborators ,
¶List of UK GPCS Collaborators available on request.
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Colin Cooper,
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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Rosalind Eeles,
Affiliations The Institute of Cancer Research, Sutton, Surrey, United Kingdom, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
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David E. Neal
Affiliation Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, United Kingdom
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The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine
- Hayley C. Whitaker,
- Zsofia Kote-Jarai,
- Helen Ross-Adams,
- Anne Y. Warren,
- Johanna Burge,
- Anne George,
- Elizabeth Bancroft,
- Sameer Jhavar,
- Daniel Leongamornlert,
- Malgorzata Tymrakiewicz
- Published: October 13, 2010
- https://doi.org/10.1371/journal.pone.0013363