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Research Article

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

  • Morgane Rolland mail,

    mrolland@u.washington.edu

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Jonathan M. Carlson,

    Affiliation: Microsoft Research, Redmond, Washington, United States of America

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  • Siriphan Manocheewa,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • J. Victor Swain,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Erinn Lanxon-Cookson,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Wenjie Deng,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Christine M. Rousseau,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    Current address: Bill and Melinda Gates Foundation, Seattle, Washington, United States of America

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  • Dana N. Raugi,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Gerald H. Learn,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Brandon S. Maust,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Hoosen Coovadia,

    Affiliation: HIV Pathogenesis Program, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

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  • Thumbi Ndung'u,

    Affiliation: HIV Pathogenesis Program, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

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  • Philip J. R. Goulder,

    Affiliations: HIV Pathogenesis Program, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, Department of Pediatrics, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom, Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Bruce D. Walker,

    Affiliations: Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Christian Brander,

    Affiliation: Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Laboratori de Retrovirologia, FundaciĆ³ irsiCaixa, Barcelona, Spain

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  • David E. Heckerman,

    Affiliation: Microsoft Research, Redmond, Washington, United States of America

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  • James I. Mullins

    Affiliations: Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Published: September 01, 2010
  • DOI: 10.1371/journal.pone.0012463

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