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Research Article

A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia

  • Eliot B. Friedman,

    Affiliations: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Yi Sun,

    Affiliation: Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Jason T. Moore,

    Affiliations: Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Hsiao-Tung Hung,

    Affiliations: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Qing Cheng Meng,

    Affiliation: Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Priyan Perera,

    Affiliation: Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • William J. Joiner,

    Affiliation: Howard Hughes Medical Institute, Philadelphia, Pennsylvania, United States of America

    Current address: Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

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  • Steven A. Thomas,

    Affiliation: Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Roderic G. Eckenhoff,

    Affiliation: Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Amita Sehgal,

    Affiliations: Howard Hughes Medical Institute, Philadelphia, Pennsylvania, United States of America, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Max B. Kelz mail

    kelzma@uphs.upenn.edu

    Affiliations: Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: July 30, 2010
  • DOI: 10.1371/journal.pone.0011903

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