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Research Article

Phosphodiesterase Type 5 Inhibitors Increase Herceptin Transport and Treatment Efficacy in Mouse Metastatic Brain Tumor Models

  • Jinwei Hu equal contributor,

    equal contributor Contributed equally to this work with: Jinwei Hu, Julia Y. Ljubimova

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Julia Y. Ljubimova equal contributor mail,

    equal contributor Contributed equally to this work with: Jinwei Hu, Julia Y. Ljubimova

    ljubimovaj@cshs.org

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Satoshi Inoue,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Bindu Konda,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Rameshwar Patil,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

    X
  • Hui Ding,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Andres Espinoza,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Kolja A. Wawrowsky,

    Affiliation: Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Chirag Patil,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Alexander V. Ljubimov,

    Affiliations: Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America

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  • Keith L. Black

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Published: April 19, 2010
  • DOI: 10.1371/journal.pone.0010108

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