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Research Article

Natural Triterpenic Diols Promote Apoptosis in Astrocytoma Cells through ROS-Mediated Mitochondrial Depolarization and JNK Activation

  • Rubén Martín,

    Affiliation: Instituto de Biología y Genética Molecular, CSIC-Universidad de Valladolid, Valladolid, Spain

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  • Elvira Ibeas,

    Affiliation: Instituto de Biología y Genética Molecular, CSIC-Universidad de Valladolid, Valladolid, Spain

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  • Juliana Carvalho-Tavares,

    Affiliation: Instituto de Biología y Genética Molecular, CSIC-Universidad de Valladolid, Valladolid, Spain

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  • Marita Hernández,

    Affiliation: Instituto de Biología y Genética Molecular, CSIC-Universidad de Valladolid, Valladolid, Spain

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  • Valentina Ruiz-Gutierrez,

    Affiliation: Instituto de la Grasa de Sevilla (CSIC), Sevilla, Spain

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  • María Luisa Nieto mail

    mlnieto@ibgm.uva.es

    Affiliation: Instituto de Biología y Genética Molecular, CSIC-Universidad de Valladolid, Valladolid, Spain

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  • Published: June 22, 2009
  • DOI: 10.1371/journal.pone.0005975

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