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Research Article

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

  • Christelle Cabrol,

    Affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

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  • Malwina A. Huzarska,

    Affiliation: Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America

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  • Christopher Dinolfo,

    Affiliation: Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America

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  • Maria C. Rodriguez,

    Affiliation: Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America

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  • Lael Reinstatler,

    Affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

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  • Jake Ni,

    Affiliation: Laboratory for Drug Discovery, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Li-An Yeh,

    Affiliation: Laboratory for Drug Discovery, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Gregory D. Cuny,

    Affiliation: Laboratory for Drug Discovery, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Ross L. Stein,

    Affiliation: Laboratory for Drug Discovery, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Dennis J. Selkoe,

    Affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Malcolm A. Leissring mail

    Leissring@mayo.edu

    Affiliations: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: April 22, 2009
  • DOI: 10.1371/journal.pone.0005274

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