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Research Article

Structural Basis and Catalytic Mechanism for the Dual Functional Endo-β-N-Acetylglucosaminidase A

  • Jie Yin equal contributor,

    equal contributor Contributed equally to this work with: Jie Yin, Lei Li

    Affiliations: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Graduate School of the Chinese Academy of Sciences, Beijing, China

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  • Lei Li equal contributor,

    equal contributor Contributed equally to this work with: Jie Yin, Lei Li

    Affiliations: National Glycoengineering Research Center and The State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, Shandong, China, Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America

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  • Neil Shaw,

    Affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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  • Yang Li,

    Affiliations: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Graduate School of the Chinese Academy of Sciences, Beijing, China

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  • Jing Katherine Song,

    Affiliation: Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America

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  • Wenpeng Zhang,

    Affiliation: Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America

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  • Chengfeng Xia,

    Affiliation: Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America

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  • Rongguang Zhang,

    Affiliation: Structural Biology Center, Advanced Photon Source, Argonne National Laboratory, Illinois, United States of America

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  • Andrzej Joachimiak,

    Affiliation: Structural Biology Center, Advanced Photon Source, Argonne National Laboratory, Illinois, United States of America

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  • Hou-Cheng Zhang,

    Affiliation: National Glycoengineering Research Center and The State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, Shandong, China

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  • Lai-Xi Wang,

    Affiliation: Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Zhi-Jie Liu mail,

    zjliu@ibp.ac.cn (Z-JL); pwang@sdu.edu.cn (PW)

    Affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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  • Peng Wang mail

    zjliu@ibp.ac.cn (Z-JL); pwang@sdu.edu.cn (PW)

    Affiliations: National Glycoengineering Research Center and The State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, Shandong, China, Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio, United States of America, College of Pharmacy and The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

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  • Published: March 02, 2009
  • DOI: 10.1371/journal.pone.0004658

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