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Research Article

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

  • Mark Throsby,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Merus BV, Utrecht, The Netherlands

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  • Edward van den Brink,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Genmab, Utrecht, The Netherlands

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  • Mandy Jongeneelen,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

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  • Leo L. M. Poon,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China

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  • Philippe Alard,

    Affiliation: Algonomics NV, Gent-Zwijnaarde, Belgium

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  • Lisette Cornelissen,

    Affiliation: Central Veterinary Institute, Wageningen University, Lelystad, The Netherlands

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  • Arjen Bakker,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: AIMM BV, Amsterdam, The Netherlands

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  • Freek Cox,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Merus BV, Utrecht, The Netherlands

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  • Els van Deventer,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

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  • Yi Guan,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China

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  • Jindrich Cinatl,

    Affiliation: Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Jan ter Meulen,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Merck Research Laboratories, West Point, Pennsylvania, United States of America

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  • Ignace Lasters,

    Affiliation: Algonomics NV, Gent-Zwijnaarde, Belgium

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  • Rita Carsetti,

    Affiliation: Laboratory of Cell Biology, Bambino Gesu Children's Research Hospital, Rome, Italy

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  • Malik Peiris,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China

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  • John de Kruif,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Merus BV, Utrecht, The Netherlands

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  • Jaap Goudsmit mail

    j.goudsmit@crucell.com

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

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  • Published: December 16, 2008
  • DOI: 10.1371/journal.pone.0003942

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