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Research Article

Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

  • Tao Yang equal contributor,

    equal contributor Contributed equally to this work with: Tao Yang, Juliet K. Knowles

    Affiliations: Department of Neurology and Neurological Science, Stanford University, Stanford, California, United States of America, Department of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Juliet K. Knowles equal contributor,

    equal contributor Contributed equally to this work with: Tao Yang, Juliet K. Knowles

    Affiliations: Department of Neurology and Neurological Science, Stanford University, Stanford, California, United States of America, Department of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Qun Lu,

    Affiliation: Department of Anatomy and Cell Biology, The Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States of America

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  • Hong Zhang,

    Affiliation: Department of Pathology and Taub Institute, Columbia University, New York, New York, United States of America

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  • Ottavio Arancio,

    Affiliation: Department of Pathology and Taub Institute, Columbia University, New York, New York, United States of America

    X
  • Laura A. Moore,

    Affiliation: Department of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Timothy Chang,

    Affiliation: Department of Neurology and Neurological Science, Stanford University, Stanford, California, United States of America

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  • Qian Wang,

    Affiliation: Department of Neurology and Neurological Science, Stanford University, Stanford, California, United States of America

    X
  • Katrin Andreasson,

    Affiliation: Department of Neurology and Neurological Science, Stanford University, Stanford, California, United States of America

    X
  • Jayakumar Rajadas,

    Affiliations: Department of Neurology and Neurological Science, Stanford University, Stanford, California, United States of America, Department of Chemical Engineering, Stanford University, Stanford, California, United States of America

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  • Gerald G. Fuller,

    Affiliation: Department of Chemical Engineering, Stanford University, Stanford, California, United States of America

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  • Youmei Xie,

    Affiliation: Department of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Stephen M. Massa,

    Affiliation: Department of Neurology and Laboratory for Computational Neurochemistry and Drug Discovery, San Francisco Veterans Affairs Medical Center, and Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

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  • Frank M. Longo mail

    longo@stanford.edu

    Affiliations: Department of Neurology and Neurological Science, Stanford University, Stanford, California, United States of America, Department of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: November 03, 2008
  • DOI: 10.1371/journal.pone.0003604

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