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Research Article

Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region

  • Fernando E. Herrera equal contributor,

    equal contributor Contributed equally to this work with: Fernando E. Herrera, Alessandra Chesi

    Affiliations: International School for Advanced Studies (SISSA), INFM DEMOCRITOS, Trieste, Italy, Italian Institute of Technology- SISSA Unit, Trieste, Italy

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  • Alessandra Chesi equal contributor,

    equal contributor Contributed equally to this work with: Fernando E. Herrera, Alessandra Chesi

    Affiliations: Italian Institute of Technology- SISSA Unit, Trieste, Italy, Sector of Neurobiology, International School for Advanced Studies (SISSA), Basovizza, Trieste, Italy, The Giovanni Armenise-Harvard Foundation Laboratory, Sector of Neurobiology, International School for Advanced Studies (SISSA), AREA Science Park, Trieste, Italy

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  • Katerina E. Paleologou,

    Affiliation: Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

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  • Adrian Schmid,

    Affiliation: Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

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  • Adriana Munoz,

    Affiliations: International School for Advanced Studies (SISSA), INFM DEMOCRITOS, Trieste, Italy, Italian Institute of Technology- SISSA Unit, Trieste, Italy, Sector of Neurobiology, International School for Advanced Studies (SISSA), Basovizza, Trieste, Italy, The Giovanni Armenise-Harvard Foundation Laboratory, Sector of Neurobiology, International School for Advanced Studies (SISSA), AREA Science Park, Trieste, Italy

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  • Michele Vendruscolo,

    Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, United Kingdom

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  • Stefano Gustincich mail,

    gustinci@sissa.it (SG); carloni@sissa.it (PC)

    Affiliations: Italian Institute of Technology- SISSA Unit, Trieste, Italy, Sector of Neurobiology, International School for Advanced Studies (SISSA), Basovizza, Trieste, Italy, The Giovanni Armenise-Harvard Foundation Laboratory, Sector of Neurobiology, International School for Advanced Studies (SISSA), AREA Science Park, Trieste, Italy

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  • Hilal A. Lashuel,

    Affiliation: Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

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  • Paolo Carloni mail

    gustinci@sissa.it (SG); carloni@sissa.it (PC)

    Affiliations: International School for Advanced Studies (SISSA), INFM DEMOCRITOS, Trieste, Italy, Italian Institute of Technology- SISSA Unit, Trieste, Italy

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  • Published: October 14, 2008
  • DOI: 10.1371/journal.pone.0003394

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