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Research Article

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

  • Federica Chiara,

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Diego Castellaro,

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Oriano Marin,

    Affiliation: Department of Biological Chemistry and Venetian Institute of Molecular Medicine (VIMM), University of Padova, Padova, Italy

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  • Valeria Petronilli,

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • William S. Brusilow,

    Affiliation: Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

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  • Magdalena Juhaszova,

    Affiliation: Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Steven J. Sollott,

    Affiliation: Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Michael Forte,

    Affiliation: Vollum Institute, Oregon Health & Science University, Portland, Oregon, United States of America

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  • Paolo Bernardi mail,

    bernardi@bio.unipd.it (PB); rasola@bio.unipd.it (AR)

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Andrea Rasola mail

    bernardi@bio.unipd.it (PB); rasola@bio.unipd.it (AR)

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Published: March 19, 2008
  • DOI: 10.1371/journal.pone.0001852

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